Available literature reveals that more than 400 plant species have been claimed to have anti hyperglycemic activity. The administration of extract reported significant reduction in paw swelling on 4 th,8 th,14 th and 21 st day after subplenter administration of complete freunds adjuvant. Phytochemical screening and in vitro bioactivities of the extracts of. A study was carried out to investigate the effects of daily oral administration of aqueous solution of boerhaavia diffusa l. Boerhavia diffusa bd is a plant of rasayana category as per ayurvedic claims. It is also used for the treatment of liver disorders such as hepatitis and jaundice. Ethnopharmacological use of roots of boerhaavia diffusa b. This is also known as spiderlings as this plant grows low and spreads like spider web. Enrichment of flavonoids from the methanolic extract of. The study indicates that boerhaavia diffusa and ethanolic extracts exhibit significant anti hyperglycemic activities in alloxan induced as well as streptazotocin induced hyperglycemic rats.
Boerhaavia diffusa inhibits key enzymes linked to type 2. Boerhavia diffusa is identified by name punarnava in india. List of plants phytoconstituents having insulin secretagogues or insulin mimetic activity. Antidiabetic and antihyperlipidemic activity of roots of. Kaur, anti convulsant activity of boerhaavia diffusa. Pdf phytochemical screening and in vitro bioactivities of the. Antihyperglycaemic and renoprotective effects of ethanolic extracts of b. In different areas of the world, boerhaavia diffusa has also been used for pain relief, anti inflammation, and treating indigestion. Evidencebased complementary and alternative medicine. Evaluation of insulin potentiating activity of ethanolic root. Phytochemical screening and in vitro bioactivities of the. Boerhaavia diffusa is a tropical crawling root plant, with bioactive compounds in both.
Oral administration of the ethanol extract, juice and oil of allium sativum has remarkably blood sugar lowering effect in normal and alloxaninduced diabetic rats. An overview on antidiabetic medicinal plants having insulin. There was a significant delay in the onset of convulsions and reduction in mortality at all the three doses of crude extract fraction 1, 1500 and 2000 mg k in ptz model, as compared with vehicle control. Antidiabetic activity of boerhaavia diffusa l effect on.
Antimicrobial activity study of ethanolic extract of. Boerhavia diffusa is a species of flowering plant in the four oclock family which is commonly known as punarnava meaning that which rejuvenates or renews the body in ayurveda, red spiderling, spreading hogweed, or tarvine. Botanical charecteristics of boerhaavia diffusa 3 % boerhaavia diffusa boerhaavia elegans plant a perennial herb from a fusiform root an erect glabrous shrub stem prostrate, decumbent or ascending, 410 cm long, rather slender, divaricately branched annual, woody below, glabrous above, thinly pubescent near the base. Phytochemical and biological importance of boerhavia. Boerhavia diffusa, antioxidant, cytotoxic, thrombolytic.
Antidiabetic activity of boerhaavia diffusa l effect on hepatic key enzymes in experimental diabetes article in journal of ethnopharmacology 911. The identification of phytoconstituents and assay of antioxidant, thrombolytic, cytotoxic. The present study was designed to investigate the antihyperlipidemic activity of an aqueous extract of boerhavia diffusa leaves in alloxan diabetic rats. Boerhaavia diffusa, a perennial creeping weed found in tropics and subtropics is a well known. The findings of the present study suggested that the methanolic extract of b.
Studies are in progress in our laboratory to elucidate the active components responsible for the. Boerhaavia diffusa supplement health benefits, dosage, side. The study proved that the active anti nociceptive principle of b. Several researchers have confirmed biological, pharmacological and clinical activities of the plant and its phyto constituents. Boerhaavia diffusa supplement health benefits, dosage. Historically, boerhaavia diffusa has been used for its anti diabetic and diuretic properties. An overview of chemical constituent of the plant, their pharmacological actions and clinical studies are summarized in the present paper. This model was suitable for testing our hypothesis that the anticonvulsant activity of b. Green synthesis and characterization of silver nanoparticles. Hyperlipidemia is an associated complication of diabetes mellitus. Boerhaavia diffusa, ethnobotany, phytochemistry, pharmacology. The present study investigated the in vitro and ex vivo antioxidant, anti diabetic and antiobesogenic potentials of different solvent ethyl acetate, ethanol and water extracts from the aerial parts of boerhaavia diffusa. Allium sativum alliaceae antihyperglycemic activity of ethyl ether extract at 0.
Based on the wound healing and anti diarrheal activity present study was carried out to evaluate both anti bacterial and antifungal activity of aforementioned plant 6,7. They can also improve the condition of diabetes as indicated by parameters like body weight along with serum cholesterol and triglyceride levels. Phytochemical and biological importance of boerhavia diffusa. In such circumstances, herbal medicines for the treatment of diabetes become significant. One such common plant is boerhaavia diffusa belongs to family nyctaginaceae has been explored by many research articles with a wide prospective angle to its ethnopharmacological significance, phytoconstituents, and its biological activities. Methanol extract showed higher antioxidant, thrombolytic activity and less cytotoxic activity than those of nhexane and ethyl acetate extracts of b. Diffusa roots against streptozotocin stz induced experimental rats. The activity of blet was better than glibenclamide. In vitro antidiabetic activity of polar and nonpolar solvent.
Ic 50 values indicated that ethanolic extract of the plant has more scavenging activities and reducing power than. All the extracts showed significant inhibitory activity against candida albicuns, at a. The present study was aimed to evaluate the anti diabetic activity potential of boerhaavia. The immunomodulatory activity is attributed to the compounds like quercetin, punarnavine, syringaresinol mono. Boerhaavia diffusa inhibits key enzymes linked to type 2 diabetes in vitro and in silico. Boerhavia diffusa or punarnava belongs to the family nyctaginaceae. In the present study, the antidiabetic and antihyperlipidemic potential of b. An overview on antidiabetic medicinal plants having. The mechanism of its analgesic effect was not known. In different areas of the world, boerhaavia diffusa has also been used for pain relief, antiinflammation, and treating indigestion. An overview on antidiabetic medicinal plants having insulin mimetic. The results showed that the plant extracts were a rich source of phytoconstituents.
Methanol extract showed higher antioxidant, thrombolytic activity and less cytotoxic activity than those of. As this activity retained only in liriodendrinrich fraction, this confirms that the anti convulsant activity of the crude methanolic extract is due to the presence of liriodendrin. Many herbs and spices are known to be antihyperglycemic. Results and discussion the antibacterial activity of different plant components leaf, stem and root of boerhaavia diffusa aqueous extract against salmonella typhi, staphylococcus aureus and escherichia coli were summarized in table 5. The leaves of boerhaavia diffusa are often used as a green vegetable in many parts of india and are very well known to possess medicinal properties. In ayurvedic and unani, the miracle medicinal plant finds to use as a cure for 22 ailments. Anti inflammatory activity of boerhaavia diffusa l. Among the bioactivities, antioxidant activity was the most notable compared to the positive control and thus could be a potential rich source of.
Histopathological studies also supported the antidiabetic effect of the extract. Boerhaavia diffusa is an herb found in ayurveda and other traditional medicines. Some of the promising effects of this plant include diuretic, hepatoprotective, anti inflammatory, anti fibrinolytic, anti cancer, anti diabetic, immunomodulatory, immunosuppressive, anti. In conclusion, the aqueous extract of boerhaavia diffusa leaves were found to exhibit a significant hypoglycemic and antihyperglycemic activity in normal and alloxan diabetic rats. Sep 18, 2019 boerhaavia diffusa is an herb found in ayurveda and other traditional medicines. Antidiabetic and antioxidants activity of boerhavia. In the genus boerhavia, preclinical evaluation of antidiabetic and antihyperlipidemic activity was reported only for b. Petroleum ether extract exhibited better cytotoxic activity in c2c12 cell line compared to ethanol extract concentration of test drug needed to inhibit cell growth by 50% 110. Boerhaavia diffusa contains a large number of phytoconstituents namely, flavonoids. Isolation of major phytoconstituents and standardization of different extracts of boerhavia diffusa by rphplc. The boerhaavia diffusa plant contains a large number of such compounds as flavonoids, alkaloids, steroids. Punarnavine, an alkaloid isolated from this plant has been shown in vitro to possess anti cancer, anti estrogenic, anti amoebic and immune modulatory activities selvaraj et al. Rjpt pharmacological activities of boerhaavia diffusa.
The study was designed to investigate the methanolic root extract of b. Ayurvedic texts hugely praise the medicinal properties of this plant. Detail study on boerhaavia diffusa plant for its medicinal. Boerhaavia diffusa nyctaginaceae chloroform extracts of leaves of boerhaavia diffusa showed antidiabetic activity in streptozotocin induced diabetic rats which mainly act by reducing blood glucose level and increasing insulin sensitivity.
The present study was aimed to evaluate the anti diabetic activity potential of boerhaavia diffusa roots against streptozotocin stz induced experimental rats. The effect of petroleum ether and methanol crude extracts and phytoconstituents from b. Flavonoidsrotenoids present in boerhaavia diffusa is known for its different biological activities such as antioxidant, anti diabetic, anti stress, anticonvulsant, antibacterial, hypoglycemic, anti nociceptive, hepatoprotective, anti proliferative and anti estrogenic, anti inflammatory. Pdf to investigate the bioactivities of crude nhexane, ethyl acetate and methanol extracts of aerial part of boerhavia diffusa linn. It is the best natural diuretic and beneficial in renal and urinary conditions. Effect on serum and tissue lipids in experimental diabetes article pdf available in journal of medicinal food 74.
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